The global number of unexplained hepatitis cases in children has reached 450, including 11 deaths, according to an update from the European Centers for Disease Control and Prevention.
These cases come from two dozen countries around the world, with some more than five cases in 14 countries. The countries with the highest number of cases so far are the UK and the US.
In the UK, authorities have identified 163 children under the age of 11 who required liver transplant surgery. Last week, the U.S. Centers for Disease Control reported that 109 cases of children under the age of 10 were being investigated in 25 states. Of those cases, 14 percent required liver transplant surgery, and five children died.
There are a total of 106 cases in 14 EU countries, with Italy (35) and Spain (22) having the highest number of EU member states. Outside the EU, authorities have registered cases in Argentina (8), Brazil (16), Canada (7), Costa Rica (2), Indonesia (15), Israel (12), Japan (7) and Panama (1). ) Has been registered. ,,) Palestine (1), Serbia (1), Singapore (1), South Korea (1).
Eleven deaths have occurred in Indonesia (5), Palestine (1) and the United States (5).
Despite the increasing number, the cause of acute hepatitis-hepatitis remains a mystery. Some cases have been identified since October 1, 2021.
Health officials around the world are monitoring cases of children with severe hepatitis that cannot be explained by common culprits such as hepatitis A, B, C, D and E viruses. People with cases also have high levels of liver enzymes.
“Currently, the leading hypotheses are related to adenovirus,” World Health Organization senior scientist Philip Esterbrook told a news conference Tuesday.
“But,” he added, “the role of the government is very important, whether it’s accidental or past epidemics.”
Esterbrook noted that about 70 percent of cases tested for adenovirus were positive, and that adenovirus type 41 was followed by subtype testing.
Adenoviruses do not cause hepatitis in healthy children, although a large family of viruses has previously been linked to liver damage in children with compromised immune systems. Adenoviruses often cause common respiratory infections in healthy children, while type 41 is associated with gastrointestinal disease.
Liver biopsy data show that there is no adenovirus in the liver of infected children, and this raises questions. In addition, adenoviruses are more common in children, and some cases of hepatitis occur when the incidence of adenovirus is high in the general population. This raises the possibility that the diagnosis of adenovirus is accidental and does not cause liver damage.
At a news conference on Tuesday, Easterbrook pointed out this possibility: “We hope to be able to compare UK data within a week on a [critical] case-control study to see if adenoids develop in children with liver disease.” The detection rate is different “.,
It really helps to know if there is an accidental infection or if there is a causal or possible causal link to the diagnosis of adeno. ”
Otherwise, without regular exposure to drugs, food, beverages, toxins or travel, cases would be rare and unrelated, officials said. The US CDC has ruled out a rare genetic condition called Wilson’s disease based on data on bacterial infections, urinary tract infections, autoimmune hepatitis and cases in Alabama.
According to Easterbrook, 18 percent of cases tested positive for SARS-CoV-2. However, the US CDC rejected the direct cause of SARS-CoV-2 activity, noting that the first nine cases identified in Alabama were antivirals.
At a news conference last week, Jay Butler, CDC’s deputy director for infectious diseases, said the company still has the potential to play a role in the past events of SARS-CoV-2 infection.